The article shows the opportunities of meta-theoretical approach to the interdisciplinary analysis and synthesis of economic knowledge on the inter-theoretic and mathematic basis through a bundle of a manifold (environment) as the relationship of indicators providing economic and scientific activity. The main equations of factor dependencies and temporal variability are found to determine the evaluation functions of the life quality and to model the innovation processes. As an example for the concept of the price, the economic knowledge distribution on inter-theories is demonstrated. Using patterns of political and economic relations, the author illustrates the procedure of interpretation of general systems concepts and axioms in terms of the conception of sustainable development. Analytic bundle of a manifold of the geographical environment and functional comparison of layers gives the possibility to take into account in economic models the particularities of the location, allow assessing the economic environment of activity, comparing economic segments (regions, industries) and studying the territorial organization. The opportunities of the approach are illustrated in the example of the connection of investment and overall production in the region.